I voted for the .308. It has a wider bullet weight choice. If you handload you can stuff it with 125 gr. varmint bullets or you can stuff it with 200 gr. moose bullets. The .308 is very versatile. And I personally like a little more energy delivered at impact. So I shoot a .270 and I have only had one deer run and it was my fault. But a buddy of mine likes to use his .243 and they always seem to go at least 40 yards which he even told me when we went hunting this past year. But I hit one with that .270 and it is lights out. And a .308 would hit the same or harder than a .270. A .243 will get it done but I do not like to track my deer.