Of the three there is no doubt in my mind, 280 Rem. What I think might be as good or better on a long action is a 6.5x06. I have one and it is super. You said your gonna get back into reloading so it would work fine. And of course for deer and hogs, why look past the 25-06? For deer and hogs I can't see any advantage of cartridges having heavier bullet's.

If all else fails, get a 50BMG, you'll need a long action for it!