The 300grn Bloodline
should exit every time. Of course there are exceptions with all bullets. Once people understand how this bullet works, they will see that bigger isn't always better.
After reading some of your post and people losing game, i think you will love the Bloodlines. Those petals shear and get into the vitals and cause damage and even more trauma. They even help when a bad shot is made.
I have done a lot of testing on game and on targets. I really believe this is the best ML bullet made today. Now it's for sure the best bullet i ever used. I will say, i never used any Nosler bullets. Below are some examples of performance on game.