The biggest problem with .45's really is bullet selection. There just isn't enough. There are only 2 (200gr sst and 195gr bx) that are made for muzzleloaders and the velocities they shoot. I know people shoot the 200gr xtp with some success, but I have heard too many reports of it being fragile for me to risk it. There is also PR bullets, but expensive lead bullets aren't apealling to me not to mention their velocity limitations. I read a thread where 180gr gold dots where coming apart at 10mm speeds...... The .45 market is a niche within a niche so I don't really see manufactures spending a lot of time and money to develop more options.. I think if they could get the twist rate and sabots right to shoot .375 rifle bullets they would be on to something though.