Felt recoil will be the worst draw back. Second thing I could see would be if you like shooting at the range a lot then you would have issues with the barrel heating up. I have shot my friend's featherweight 30-06 with 220gr bullets and also shot them in a standard weight. The featherweight felt like I was shooting a single shot 10ga with heavy 3.5" duck/geese load. I am not very recoil sensitive and I do prefer light weight rifles. I sold my Remington Sendero in 300WM because it was to heavy. I now have a Model 7 in .350 Rem Mag. Gun without scope is 6lb. With scope and sling I am now around 7.5lb loaded. A bit less than the 10lb+ Sendero. Recoil is a little stiffer with the .350RM but it doesn't really bother me.