A few years ago I was presented this shot for several minutes and recalled long ago during the archery license class this was qualified a "not to shoot" situation...well after a bit I couldn't help myself so I did draw and did not get busted by the buck; what I did realize though was that while my pins showed a clear shot, the arrow was pointing at my foot!
I'd say if the deer is
directly under your stand, as was my case, you wait until it moves out for an archery shot
Firearms? Probably still better to wait, but I will admit to shooting straight down between the shoulders before.