It's definitely worth a try
Brknarrow. You just never know what a particular barrel will do.
I no longer have any 1:48 twist barrels, so don't have any recent experience. But several years ago I tried a few sabot loads in a New Englander with so-so results. Though, as I recall, I only tried one bullet weight it it. I also had a Pedersoli .50 caliber Dixie Cub with a 1:48 twist that shot 250 grain XTPs in H5045SB sabots quite well.
If you want a definite sabot shooting sidelock, get yourself a 1:28 twist Green Mountain LRH (Long Range Hunter) barrel for one of those Renegades. That barrel will make you smile for sure.
Here's the best 100 yard target I've shot with my peep sighted TC Hawken with a LRH barrel.