In my many years as a deer hunter (3) every deer I have shot with a rifle (3) has been with a 30-06 with 150 grain corloks. Each of those three deer was hit slightly far back, just nicking the front of the stomach (yes, I need to not be afraid to nick the shoulder and I need to be a better judge of the deer's angle to me), and yet each of those deer went less than 20 yards before falling down. Based on that I would have to say 30-06.

I do have a Marlin 336 in 35 Remington ready for this season, and I hope to see if the 200 grain corelock pill will work, and if so that may be my favorite:-)