I think you know where I am going with this but in a polite way I am going to take it one step further.
So from this chart we can say that, according to Knight's own safety people, We could safely shoot a 375 grain redhot bullet in front of 150 grains of bh209 in a Knight Bighorn 52 caliber rifle. In fact the minimum charge they would recommend would be 130 grains.

PS. I would not recommend it.