a·nath·e·ma

   [uh-nath-uh-muh] Show IPA
noun, plural -mas. 1. a person or thing detested or loathed: That subject is anathema to him.

2. a person or thing accursed or consigned to damnation or destruction.

3. a formal ecclesiastical curse involving excommunication.

4. any imprecation of divine punishment.

5. a curse; execration.