i did it. when i was 12 got my first bow that was right handed. i shot good but not great. took my first deer with it. since my left eye was dominant i started to shoot my rifle left handed. then last year i used my right handed bow, but used it left handed. even though it wasnt the best i made my grouping so much smaller, then i took my last deer left handed with a right hand bow. Now i got a new bow that is left handed, and lets just says i can drill a baseball at 30 yards. Its not as hard as i thought it would be but i think it makes a huge difference! it was a little difficult to gain as much strength in my left arm to pull back, but i started at 50 and now am at 70 comfortably. i also shoot with both eyes open which i did see an increase in accuracy after i changed. i say go for it!