The bullet knows not what it's fired from, so it doesn't know if it's in a .45LC round or a reduced 454 round. The .45LC is completely interchangeable in a 454C gun, just like the 44mag/44spcl and 357/38spcl. So Good way to enjoy shooting and practice without burning more powder, stressing your gun (and hand) and saves on wearing your cases. (Tho I'd honestly just buy or get some spent 45LC brass for reduced loads instead of stretching your much more expensive 454 brass!)

Enjoy,
HL