It really is not that simple, you load and your capabilities enter into it. As a general rule the construction of the bullet would have as much to do with it as the weight. Then we get into velocity some guns are capable of much more pressure and controlling the with than others. The loads I use with some bullets in my Encore Endeavor would probably shock you but the only other guns that are capable of that kind of pressure are the Knight [the old ones I have not tested the new ones] the White and the Savage. But to get back to the point if a bullet starts out at 2300 FPS say a 250 gr with a good BC it ends up with enough Foot lbs of energy that it can do a job that the same bullet stating out at the more normal 1700 or 1800 FPS is less than capable of.