The 250 grain I believe is fine for deer. Some people even shoot them with smaller projectiles like a 200 grain.

I was shooting some Lehigh 200 grain .40 caliber and just for fun I shot a 1/2 gallon milk jug at 100 yards. The jug was of course filled with water. I could not believe it, but I had just little chunks of that jug left down range. That really impressed me, and that's not easy to do. I think that would make just an excellent little deer bullet. I was pushing it at 110 grains of Triple Seven (as Grouse once suggested to me.. thanks) and I would not be afraid to shoot a deer at 200 yards with that at all. Maybe I am wrong. But I think bullet design plays a big factor as well as shot placement in determining what kind of wound will happen.