Well from my records I normally start at 80 grains when checking for an accuracy load so I have the 300 gr GD figures for that for 100 yds 1705 Foot Pounds
For the 250 with my triumph deer load of 110 grains I have figured 1560 Foot Pounds for 100 yds.
Now since a 250 GD will drop a deer on the spot with 850 FP at long range which I know because I have done it. The only advantage I can see would be if the deer were standing one behind the other and you were trying for more than one, which I would not do any way and since I do use the 300 for bigger game like elk the only real difference I see here is in the trajectory.
Guess how much that is.