Shot placement is everything. i want the animal to suffer as little as possible. Couple of years ago i had to re-group after some long tracking and dragging jobs. For years i used 130-150 grain loads of Pyrodex RS: Those loads knocked deer and hogs stone dead. Now my loads are 100 grains and they also kill well. My Encore is an exception: It's sighted in for 140 grains of Pinnacle 3F and the 250 grain SST/Shockwave bullet.
i'm 72 years old and in very good shape for hunting. i hunt mostly alone. When i do hunt with other folks they are usually much younger. Got tired of listening to guys my age whine about the heat, the cold, aches and pains. i've got aches and pains too: They seem to go away when i'm hunting.