When I was playing around with my .45 GM/LRH Renegade I shot GOEX loads starting at 85 grains and moving in 10 grain increments up to 125 grains. I got velocity increases with each 10 grain bump in powder - about a 250 fps spread from bottom to top. But the 85 grain load was the most accurate. And at around 1750 fps it had all of the killing power I need for my 150 yards or less hunting situation.

I also shot T7 in ten grain increments from 60 grains (1566 fps) to 110 grains (2037 fps). But the 80 grain load at around 1775 fps was the most accurate.