Cayugad I've always shot FFFg Goex out of my 45s. Even some of my 50s. For a first outing with these bullets, they do show promise. When I shoot my GM LRH 45 with the blue Harvester CR sabots and 200 gr .400 XTPs it gets excellent accuracy with 80 gr of Pyrodex P.
Perhaps you may want to drop your charge down a bit and see if things improve.