Yes, I have on many different occasions...

For me different primers have caused a shift in POI, but not really group size.

The POI is not really that significant either... I'l see if I can find an example....

This was a target shot using the same load for each but changing the primer. When I was shooting this target I was shooting it to test the theory that some one expressed that the hooter primer produced significant more velocities with BH than the cooler primers... bah humbug!

The target was not shot for real accurracy... as I just loaded and set down and sighted in and pulled the trigger... so a lot of those impacts out of the group were my doing - not the gun or the powder - the bullet ...