Weight is not the only consideration. The BC of a bullet not only determines the drop but also the wind drift and if two bullets with the same or close to the same have a major difference in velocity the slowest one is in the air being affected by the wind much longer. The 50/40 200gr Shock Wave with a BC of 265 and a SD of 179 is a very good hunting bullet a lot of us like the 50/40 200 gr bullet which there are several to chose from. Now I do not recommend this load especially for any one shooting something other than an Encore or a Knight. With my Endeavor and a load of 140gr of Blackhorn I clock close to 2350.
I sight in at a "0" of 170 yards I am 2.5 inches high at 100yards and 2.5 inches low at 200 yds since I do not hunt in a wind stronger than 20 mi I figure my wind drift at that speed, 100 yds drift is 3.25 200 yds wind drift is 15 inches.
I consider any thing with in 3 inches pointblank. I try very hard to use hunting skill to get close rather than shooting long distance because of the time factor. If a deer has time to take one step before the bullet gets there it can turn a good double lung shot into a gut shot.