Don't know about a .380,But I do know you can take a Beretta 92FS and change the safety and mag release to make it a lefty.Maybe go to your gun shop and see if their .380s are capable of the same.Might be worth a try.On another note I am going to call the Kimber custom shop and see if they can turn my Eclipse into a lefty only .Might have to have a new slide ? Concerned most about mag release..........Swamp