"Yes it will if everything goes right and the hunter is very patient and takes the right shot. "

Wrong attitude. I don't care if you are using a 22 or a 50 bmg. If you aren't taking a good clean kill shot, then you shouldn't be taking the shot. The .243 is a great gun for the bigger game, as are most high powered rifles. The fact that the .243 is the most popular hunting cartridge in Europe for their big game animals such as Moose and Stag seems to constantly be over looked.

On any animal shot placement is key. It's been said at least a thousand times when talking about this gun or that gun, but it is the rock solid truth. I took a nice bull elk, a nice mulie and a decent black bear last fall with my single shot .243. I hunt with it because i choose to hunt with it. I hunted with the 30'06 for over 30 years and have just last year dropped down to the 243 and i love it. If you can shoot a 243 with confidence and put the shot where you want it to be, hunt with the 243.