About 10yrs ago I was hunting a field growed up in sage grass and saplings. I climbed down about 11am and was walking back across the field when I saw a doe jump across the fence with a buck chasing her. They ran straight toward me, but turned and headed toward the woods about 100 yards in front of me, I reckon the doe must have spotted me. I followed him in my scope and touched off with the crosshairs right on the front of his chest. They werent running full blast just a good steady lope. At the shot I wasnt sure if I had hit him or not, I knew the shot felt good. Where he jumped the fence into the woods I picked up a dark blood trail, so I back out and waited a couple of hours. My wife and I came back and trailed him up. We found him in the creek dead about 250 yards from where I shot him. I had hit him a bit far back, caught the liver and the backside of the far lung. I stepped the shot off and it was 129 steps.
I realize that was probably not the most ethical shot to take. I just pulled up, followed him in the scope and shot. For many years I raised beagles and rabbit hunted all winter with a 22. I have shot lots a rabbits running with one. It did teach me how to lead on a running shot, although I admit I did hit that buck a few inches back from where I intended. I wouldnt take that shot now, because I dont feel as confidient shooting at running game as I once did. Out of practice.