Heck personaly I like my ol' 30-06 for manny reasons. Good out to 500 yards but never shot an animal over 100. Bullet for varments is a 55 grain ecelerator leaving the mussle at 4,200 fps now that is faster then a 22-250. Remington ecelerators are 20 caliber saboted to 30 caliber. Then you have your 145, 150, 165, and 180 grain bullet choises also. I use a 165 grain boat tail for deer and a 180 grain Remington core loct for elk. One rifle for all animals. The downfall would be sighting in for different animals but then again I usualy take a few shots before hunting season anyway so for me it works perfectly.