SJAdventures
As someone has already mentioned... Range is one of the key factors in my mind. The heavier projectile tends to extend the range a bit, but more importantly as the range goes up so do the external factors that can move your bullet. These external factors are probably the least thought of factors when it come to shooting the longer ranges while hunting. The lighter the bullet and quicker it looses velocity the more effect these external factors are going to have on the flight of the bullet.
Probably one of the biggest reason that some of the ML hunters think we are nuts shooting these light weight bullets vs. their 400+ grain freight trains. These big conicals are effected much less by the external factors.