I have never used anything heavier than the 240gr XTP's, shots from 0-200yds no problem. And as far as them (Tough) Deer in NC, our Deer are even Tougher and Bigger here in NY and the XTP's still put em down.
As long as you have enough Powder backing your Bullet and your shots are where they should be then you'll be just fine with the 250gr Bullett.
(BP)