Gotta love these "best caliber for" threads....

That said, and having used a .30-06 for pronghorn, I'll emphatically not recommend anything larger. Pronghorn hunters are a strange lot, though. Some will hunt them with a bow, some will launch bullets at them from the next county. So, your hunting style probably plays a part.

Personally, I've never found the need to shoot an antelope from farther than 190 yards. I spend most of my time glassing, and when I find one that I want it becomes a matter of reading the terrain - where the animals are likely to go, and then planning a stalk accordingly. As long as they don't clearly see bipedal motion (easily masked in the sagebrush), they'll often let you crawl to within 300 yards. The .243 is the undisputed king of pronghorn hunting in my battery.

Just one more thought. As you plan your hunt, also find processor nearby. Goat hunting occurs when the temps are still fairly warm, a goat can spoil easily if it's not cooled down quickly. That often requires a conveniently located cooler. Unless you have one of those neat rigs on a trailer, a processor is your best bet. Goat tastes a bit different to start with, but properly cared for, it's the perfect reward for a good hunt.