I have my "go to" hunting load combination for each gun. It's one that I have complete confidence in for that particular gun. Every one uses GOEX as the propellant with round balls, Gold Dots/Deep Curls, or XTPs as the projectiles. I like to do a "trajectory study" for the gun's load and keep the target in my file (see sample below). So when I pick a gun to hunt with all I have to do is check the study to see where the load should hit at various ranges.

But I can't help experimenting with different powders and bullets just for the heck of it. I enjoy playing around with different components, especially stuff I get cheap at end of season sales and such.