I would never go hunting a coyote with a .22 magnum, but it was at hand. Actually, the .22 mag rendered a quick, humane kill, but as it was put in the lungs, she ran a bit. I have read/heard of as well as seen on video a number of folks koll coyotes with a .22 magnum, but I prefer more stopping power. They're great as far as pelt damage, as they seldom go through.....but it makes for tough blood-trailing at times.