I bought a Ruger 1-V in .25-06 years ago. With factory loads, 2.5" to 3" groups were the norm. I started working up loads for it, and with two separate handloads, it would shoot sub .5" groups.
Being a single shot, bullets could be seated out far enough to nearly touch the lands, which helped the accuracy.
I used benchrest dies, tried neck-turning on a Forster trimmer, used CCI BR2 primers and every other trick I could. Ended up shooting great.
Based on my experience, the Ruger No. 1 is a great rifle for the handloader looking to experiment to get the greatest accuracy. They are great rifles.