A .243 has been my only centerfire since 1980 and I've killed over 200 deer with her...About 10 years ago I started killing 5-6 deer with each factory loading that my gun liked so I could compare the differences...
Frankly, the 100 gr CoreLokts killed just as well as any bullet out there...If you want a long range bullet, load up some 85gr Sierra GameKings HPBT...These bullets are actually made a little harder than the 100gr Sierra GameKing SPBT so you get more pass throughs...
While some like premium bullets in their rifles, I found the standard cup and core bullets gave faster kills on center lung shots...