Sofar i have been very impressed with the 452 250 DOA but the 458 275gr really shines IMO. I dont know if it is the ogive shape of just the extra weight.
A 458 250ish grain might be interesting too. Im going to make a Lehigh order soon and give some of the 220s a shot.
BTW that is some good shooting and out to at least 100 yards that 220 should be devastating on deer.