As long as you are using a jacketed bullet with near magnum loads you should be okay. I shot one last year in the shoulder with an 100% lead bullet and only 100gr. of powder and the bone broke but stopped the round from entering the vitals. She ran over the hill and I thought she was dead. I'm glad I reloaded before topping the hill because she was standing there looking at me when I popped over and I had to put another one in her behind the shoulder. She went 20 yards and was done. I could not believe that the bullet didn't get through the shoulder when I got up to her! Have shot the TC shockwaves through the shoulder with 150gr. of powder and they went through and through, dropping them right where they were.