I shoot both the 220 Swift and the 22-250 Rem. I load for both so cost is not considered. If you are not going to be shooting prairie dogs with it, then your biggest expendature will be at sight in. I load Ballistic tips for both. I don't keep the pelts anymore so blowing a big hole in them means they don't go anywhere after being hit. I throw mine in a ditch or into a hog lot afterwards. I have taken 'yotes over 400 yds with both with no problems. I could not pick one over the other.