builder459
Accuracy is a big part of it but IMO you wont be able to push the 300gr too hard. It will perform predictably no matter how hard you push it in a ML.
The 250gr with its huge deep hollow point might not do as well with heavy charges if the range is really close. Thats a BIG might since i have never confirmed my theory. I prefer the 250gr with around 80-100gr if there is a big chance of a really close shots. If it is more likely you will be shooting a bit further (100-150yards), either should perform very well. Past 150 yards i almost always go with a heavier bullet.
I just prefer to keep a bullet close to its designed velocity at impact.
Its only my opinion that the 300gr will get the job done at any reasonable distance with the heavier charges. More recoil IMO would be the only negative. Another reason i like the 300gr is, you can buy an even cheaper Uni-Cor 300gr soft point for practice.