Well since I had trouble with getting the Barns to open at close range and high velocity I have been using Gold Dot or Deep Curl 250 gr as they are now call I use 110 in one gun and 115 in an other of Blackhorn. Hit just about the heat all the deer I have shot with them have dropped on the spot of course part of the reason for that is where they are hit. There Is no bullet that will turn a poor hit into a good one.
For bigger animals I would use the 300 gr or a Lehigh bullet in the 275 gr and up range but the 250 Deep Curl is a very nice balance to deer and Boar. I normally have a very nice exit hole so I really don't know what more you could ask of a bullet.