First off, welcome to the site!!!
It would be helpful to know what gun you are using and what type powder you are referring to...
In my case, I use Goex FFF in both my flintlocks (a .54 and a .40) and in my Knight Disc inline...I've found that FFF burns cleaner than FF and since I am able to reduce my charge, less residue is left in the barrel...In my .54 I can shoot more shots by without cleaning the barrel then I could with FF...
I also use FFF in the barrel as well as the pan which keeps thing simple...