For game smaller than brown and grizzly bears it isn't going to make any difference what so ever. If I were wanting a brown bear rifle then I wouldn't pick either one. It'd be a .338 or .375. If you can afford a brown bear hunt then you can afford another rifle. Not that they .300 and 7mm won't get the job done but I would pick the larger bore diameter for the same reason you can't hunt Africa's dangerous game with anything less than a .375 in most places.