This depends on how easy you want to make it for yourself. You can hunt one with a 20 gauge shotgun, that works well, but some people think it's a pain to pick pellets out of the squirrel. Another method is a bolt-action, i really like rugers for their accuracy and reliability, and putting a scope on a ruger 77/22 works ok if you hunt with dogs, although its a little more expensive and if you hunt alone it can be hard to find one in the scope when they're moving around a lot. If you are going to go with a rifle, my suggestion which i highly recommend is a marlin lever action .22, they hold a lot of ammunition in their tube mags, can be reloaded at your shoulder if you miss, and are very accurate.
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