I have access to family farm land that includes thousands of prairie dogs in the surrounding pastures. That means I get tons of pd shooting opportunities. In 55 gr. 22 cal bullets for several 22-250s my preference is a Vmax. But most of my shooting is with a .20 cal and I use Sierra 32 gr. BKs and Vmaxs both with equal effectiveness.
Most any of the varmint style bullets will work well, I'd be more concerned about which is most accurate. Also some 22-250s have a 1-14 twist which will limit the use of longer bullets.