cayugad
The best bullet for me and the most devasting even on some of the marginal shots I made was the .451/260 grain Nosler Partiton on deer and the .458/300 grain Nosler Partition on elk.
Both of these provided me a margin of error and excellent blood trails when need... can not rember to many that a blood trail was needed but it was there.
Today I am shooting Lehigh's and so far they have done what I would want and would expect. As well as provinding that margin of error, but at this point I have not needed the error margin.