My son killed his first deer at age 11 a couple of years ago with a 243 and a 100grn Sierra Gameking so i know they will do the job as will Hornadys spire points. I have a friend who swears by the Nosler 100grn Partitions in his 6mm and he kills a lot of big deer with that bullet. There has been a ton of deer killed with the 243 and i think any 100grn soft point will do a fine job on deer from this caliber if put in the kill zone. I personally wouldn' t shoot a deer with a ballistic tip or any explosive type bullet from a 243 it' s just to risky with that caliber. I know others do but i just wouldn' t take the chance.