This is a fantastic discussion. I was lucky to draw a tag to hunt elk in western pennsylvania, now they may be 100 pounds shy of roosevelt elk size but 800-900 pounds is not too scoff at. I put one hole in my elk with a 150gr partition in 280 rem puttering along at a pitiful 2800 fps. The shot placement was a high shoulder at 150 yds in brush. The animal stuttered took two steps and feel down. Now I am an AVID 7mm fan, I only own one other centerfire in a caliber in something other than a 7, but....guess what it is....an '06. If you are not recoil sensitive and dont mind 24 inch+ spouts, a 7 mag is hard to beat. A 280, for me is better, I feel just as confident with my 280. But the '06 hole is not much bigger and it does have some nostalgia.