Granted, it was a 30-06 180 gr round, but I once shot a good-sized deer facing me,just nicking the breastbone @ 75 yds:
bullet must have become shrapnel upon impact w/ one part of the shoulder and entire shank ruined, one side of the neck was hamburger, @ 1/3 of the heart was missing w/ everything behind it one very messy stew. No exit wound. Luckily snow was on the ground to clean things up a bit in the field. Lead does some unexpected things.
Even w/that damage the deer managed @ 60 yd run to the field's edge.
It's a shot I probably would not choose to take again...