We shoot deer here in Pennsylvania with whatever ya got, basically. So the answers and results from places like this are going to run the length of the gamut, from .22 Hornets to .50 BMG's. I would preface my first remark with the fact that the cartridge must be a centerfire. No rimfires allowed. The mountain men will still be killing deer with lever action 30-30's, 35 Rems and the like for years to come yet, while the powerline and field watchers will be picking them off at some astounding ranges. Guess what I'm getting at is that you need or should set your sights on a rifle or shotgun that will best adapt to the type of terrain you will be in. As far as an all-around pick, (and I can hear the keyboards firing up right now) I would think the old, proven 30-06 would serve you just fine, and the yardage you metioned (100-150) could be downsized some to 50-150 in most cases around here. Practice is everything.
Last edited by Pawildman; 11-26-2010 at 12:33 PM.