I use a Browning BAR 30-06 with Federal Premium ammo with Nosler Partition bullets. This combination has knocked down in their tracks almost every deer I have shot with it. Only a couple have run and they only went 30 to 50 yards and didn't even get out of sight.

Nice thing about the partitions is they hold together and blow a nice hole clear through the deer. Leaves a nice blood trail though I haven't needed it.