If you are looking for a blood trail, I would switch to a heavier bullet. On my short list would be:

1. .452 300 grain Gold Dot
2. 45 cal 250 grain Lehigh
3. 300 grain Barnes Expander
4. 45 cal 260 or 300 grain Nosler Partition if you can find them
5. .452 300 grain XTP (non mag)

You should get pass-thrus and good blood trails with all of these