lungs and heart are great shots if broadside. ummm last fall shot an elk with my 7mm butsted both shoulders and put him down fast. shot a moose 3 years ago in the hump on top of the shoulder and that put him down like a bag of dirt heard of numerous people having that same success. my favorite shot though is when a deer is looking right at me facing my and you pick that little white patch on their neck and put a bullet through it seems to work well but you have to be a good shot. when its all said and done though heart and lungs are the easiest to hit and will always do the job.