One other thing to add, I've been shooting the .44 cal, 240 GDHP/Deep Curls with good accuracy. I got a doe this past Saturday. It was not my best shooting as I hit her a bit far back. At first I thought I missed (no blood at point of impact) but I eventually found her about 120 yds away. The shot barely nicked the lungs but the bullet destroyed the liver on it's way through (and through) with massive internal damage. At about 100 yds she really started to bleed out.
So I learned two things.
1 - even with a less than perfect shot, the Speer still wrecked enough havoc to put the deer down quickly.
2 - Always to a thorough search, even if I think I missed. Took me about an hour to find her even though she did not run too far.