Beside my bed I keep a 12 ga shotgun loaded wtih 2.75" high velocity #5 shot specifically because it will not penetrate miltiple walls and be lethal on the other side but at 20 feet is as lethal as it gets. IMO, any buck shot out of a shotgun inside a home is a recipe for disaster.

I also keep an AR15 loaded with 40 grain Nosler ballistic tips under my bed. Again the 40 grain BT will not penetrate walls and be lethal on the other side but will turn someones chest into mush.

Not for home defense, but my conceal carry weapoon, a S&W 442, is sitting on my night stand next to the shotgun.